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The anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin ligase involved in cell cycle, metabolism, DNA damage repair, autophagy, apoptosis, aging, tumors and a variety of biological processes. As an important post-translational modification, ubiquitination regulates protein degradation by the ubiquitin-proteasome system (UPS). APC/C has a large molecular weight and consists of multiple subunits.
