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Mitogen-activated protein kinases (MAPKs) are serine-threonine kinases that mediate intracellular signaling. The multifunctional mitogen-activated protein kinase (MAPK) signaling system consists of separate pathways that function to control a number of different cellular processes such as gene transcription, metabolism, motility, cell proliferation, apoptosis, synaptic plasticity and long-term memory.